corA [2019-03-31 15:54:16]

general stress protein, similar to magnesium transporter

Locus: BSU24740

Isoelectric point: 9.54

Molecular weight: 37.55 kDa

Protein length: 317 aa

Gene length: 954 bp

Function: unknown

Product: unknown

Essential: no

Synonyms: yqhC,yqxL

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Transporters → Transporters/ other → Metal ion transporter
• Cellular processes → Homeostasis → Metal ion homeostasis (K, Na, Ca, Mg) → Metal ion homeostasis/ Other
• Lifestyles → Coping with stress → General stress proteins (controlled by SigB)
• Groups of genes → Membrane proteins

Gene

Coordinates: 2,560,489 → 2,561,442

The protein

Catalyzed reaction/ biological activity

• there is no indication for an implication of CorA in Mg² uptake (based on mutant phenotypes, failure to complement mutants defective in Mg² uptake) PubMed

Structure

• 5JTG (from Themotoga maritima, C-terminal domain, aa 122-297, 28% identity)

Localization

• inner spore membrane PubMed

Expression and Regulation

Operons

• Genes: corA
  Description: PubMed

  Sigma factors

  • SigB: sigma factor, PubMed, in SigB regulon

  Regulatory mechanism

  • LexA: repression, PubMed, in LexA regulon

  Regulation

  • induced by stress (SigB) PubMed

Biological materials

Mutant

• MGNA-C473 (yqxL::erm), available at the NBRP B. subtilis, Japan
• BKE24740 (ΔcorA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTCAAGCTCCTCCAAAC, downstream forward: _UP4_TAGGATGTTTCATATTTTGT
• BKK24740 (ΔcorA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGTCAAGCTCCTCCAAAC, downstream forward: _UP4_TAGGATGTTTCATATTTTGT

References

Reviews

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Original publications

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